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Fioricet contains a combination of acetaminophen, butalbital, and caffeine. Acetaminophen is a pain reliever and fever reducer.

Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Fioricet is used to treat tension headaches that are caused by muscle contractions.

Before taking tramadol

You should not take this medication if you are allergic to tramadol, if you have ever been addicted to drugs or alcohol, or if you have ever attempted suicide.

Do not take tramadol while you are intoxicated (drunk) or taking any of the following:

• alcohol or street drugs;
• narcotic pain medicine;
• sedatives or tranquilizers (such as Valium);
• medicine for depression or anxiety; or
• medicine for mental illness (such as bipolar disorder, schizophrenia).

Seizures have occurred in some people taking tramadol. Talk with your doctor about your seizure risk, which may be higher if you have:

• a history of drug or alcohol addiction;
• a history of epilepsy or other seizure disorder;
• a history of head injury;
• a metabolic disorder; or
• if you are also taking an antidepressant, muscle relaxer, narcotic, antipsychotic, or medicine for nausea and vomiting.

To make sure you can safely take tramadol, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);
• cirrhosis or other liver disease;
• a stomach disorder; or
• a history of depression, mental illness, or thoughts of suicide.

Tramadol may be habit forming and should be used only by the person it was prescribed for. Never share tramadol with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

FDA pregnancy category C. It is not known whether tramadol will harm an unborn baby. Tramadol may cause serious or fatal side effects in a newborn if the mother uses this medication during pregnancy or labor. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Tramadol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking tramadol. Do not give this medication to anyone younger than 16 years old without the advice of a doctor.

Before taking Fioricet

Do not use Fioricet if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. You should not take Fioricet if you are allergic to acetaminophen, butalbital, or caffeine, or if you have porphyria.

To make sure you can safely take Fioricet, tell your doctor if you have any of these other conditions:

• kidney disease,
• liver disease; or
• a history of mental illness or suicidal thoughts.

Butalbital may be habit forming and should be used only by the person it was prescribed for. Never share Fioricet with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

FDA pregnancy category C. It is not known whether Fioricet will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Acetaminophen, butalbital, and caffeine can pass into breast milk and may harm a nursing baby. Do not use Fioricet without telling your doctor if you are breast-feeding a baby.

Barbiturates in general have been reported to readily cross the placental barrier. Withdrawal seizures have been reported in a two day old infant whose mother had taken a butalbital containing drug during the last two months of pregnancy. Butalbital was found in the infant’s serum. Animal reproduction studies have not been conducted on butalbital. Barbiturates are excreted in breast milk in small amounts. The significance of the effects on nursing infants has not been reported. Because of the potential for serious adverse reactions in nursing infants from butalbital, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Do not use Fioricet if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not take more Fioricet than is recommended. An overdose of acetaminophen can damage your liver or cause death. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Tramadol is a synthetic stripped-down piperidine-analog of the phenantherane alkaloid Codeine and, as such, is an Opioid and also a pro-drug (Codeine gets metabolized to Morphine, Tramadol gets converted to M-1 aka O-desdol). Opioids are chemical compounds which act upon one or more of the human opiate receptors (the euphoria, addictive nature and respiratory depression are mainly caused by the Mu(μ) 1 and 2 receptor. The opioid agonistic effect of Tramadol and its major metabolite(s) are almost exclusively mediated by the substance’s action at the μ-receptor. This characteristic distinguishes Tramadol from many other substances (including Morphine) of the opioid drug class, which generally do not possess Tramadol’s degree of subtype selectivity.

Tramadol is used similarly to Codeine, to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia. Another popular use of Tramadol is as a remedy for opiate/opioid withdrawal, especially since it being uncontrolled has led to many addicts weaning down or altogether stopping their addiction to opiates. Tramadol is like Levorphanol (albeit with much lower μ-agonism), somewhat, pharmacologically, as both opioids are also NMDA-antagonists which also have SNRI activity (other such opioids to do the same are Kratom, Dextropropoxyphene (Darvon) & M1-like molecule Tapentadol (Nucynta, a new synthetic atypical opioid m

ade to mimick the agonistic properties of Tramadol’s metabolite, M1(O-Desmethyltramadol). It has been suggested that tramadol could be effective for alleviating symptoms of depression, anxiety, and phobiasbecause of its action on the noradrenergic and serotonergic systems, (also) such as its “atypical” opioid activity – (function). However, health professionals have not endorsed its use for these disorders; It may be used as a unique treatment (only when other treatments failed), and must be used under control of a psychiatrist.

Fioricet Patient Reviews:

1.  I’ve had headaches since early childood and I swear I tried everything; OTC medicines, chiropractic, acupuncture, yoga, different diets, physical therapy, ultrasound. Finally after seeing a million doctors, including two neurologists and a pain specialist, I moved to a new state and started seeing a Physician’s Assistant, who prescribed me Fioricet. What a diffrence in my life. My headaches go away within an hour or so now, instead of just “waiting it out” for 3 to 6 days. I would tell anyone with TMJ and/or tension headaches to try this. It works best if you take it as soon as you feel a headache coming on. I too tried to use it as a last resort, but I have learned that it’s not worth the suffering.

2. I’ve learned to ‘live’ with headaches; often lasting up to four days or more. I was prescribed Fioricet about two years ago and I find it to be a relief not to have to ‘live’ with a headache for days anymore. I’m careful about using it and often as a last resort after trying Advil and the like. Therefore I don’t find it habit forming for me. It is an absolute relief drug.

3. I suffer from TMJ syndrome and sinusitis. I have recurring headaches. I have taken this drug on/off for 12 years. I am allergic to a lot of meds, so it’s been well-suited for me. I do know it is habit forming, as if I have to take it for several days, I do have some withdrawl symptoms.

4. I have been a suffering from migraine headaches for 20 years. I’ve tried EVERYTHING. My experience has shown if you take 2 tablets of Fioricet at the onset of one, you will do yourself a huge favor. It works. It may not eliminate your migraine but it will make it tolerable and less severe. Like others above, you have to be careful about how much you do take. I’ve found if I had a bad headache and have taken several pills, I have to then ween myself off of it by taking one pill every 4 hours over the next day or so to prevent a rebound headache. If you take many of these to relieve a headache, I recommend taking a few when your headache is gone to prevent a rebound. I make sure I carry my Fioricet with me at all times.

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